Peripheral versus central mechanisms of the cannabinoid type 2 receptor agonist AM1710 in a mouse model of neuropathic pain

The CB(2)R agonist AM1710, examined in animal models of peripheral neuropathy, is effective in controlling aberrant light touch sensitivity, referred to as mechanical allodynia. However, nonspecific binding of AM1710 to CB(1)R, either peripherally or centrally, could be partially responsible for the...

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Detalles Bibliográficos
Autores principales: Wilkerson, Jenny L., Alberti, Lauren B., Kerwin, Audra A., Ledent, Catherine A., Thakur, Ganesh A., Makriyannis, Alexandros, Milligan, Erin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749576/
https://www.ncbi.nlm.nih.gov/pubmed/32977358
http://dx.doi.org/10.1002/brb3.1850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749576/
https://www.ncbi.nlm.nih.gov/pubmed/32977358
http://dx.doi.org/10.1002/brb3.1850

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