Cargando…

Safety and pharmacokinetics of bimagrumab in healthy older and obese adults with body composition changes in the older cohort

BACKGROUND: Bimagrumab prevents activity of myostatin and other negative regulators of skeletal muscle mass. This randomized double‐blind, placebo‐controlled study investigated safety, pharmacokinetics (PK), and pharmacodynamics of bimagrumab in healthy older and obese adults. METHODS: A cohort of o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rooks, Daniel, Petricoul, Olivier, Praestgaard, Jens, Bartlett, Michael, Laurent, Didier, Roubenoff, Ronenn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749589/ https://www.ncbi.nlm.nih.gov/pubmed/33264516 http://dx.doi.org/10.1002/jcsm.12639

Ejemplares similares

Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity: A Phase 2 Randomized Clinical Trial
por: Heymsfield, Steven B., et al.
Publicado: (2021)

Effect of bimagrumab on thigh muscle volume and composition in men with casting‐induced atrophy
por: Rooks, Daniel S., et al.
Publicado: (2017)

Bimagrumab vs Optimized Standard of Care for Treatment of Sarcopenia in Community-Dwelling Older Adults: A Randomized Clinical Trial
por: Rooks, Daniel, et al.
Publicado: (2020)

Rheumatoid cachexia: a complication of rheumatoid arthritis moves into the 21st century
por: Roubenoff, Ronenn
Publicado: (2009)

Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes
por: Brooks, Naomi, et al.
Publicado: (2006)

Continuous Digital Monitoring of Walking Speed in Frail Elderly Patients: Noninterventional Validation Study and Longitudinal Clinical Trial
por: Mueller, Arne, et al.
Publicado: (2019)

Next Generation Antiobesity Medications: Setmelanotide, Semaglutide, Tirzepatide and Bimagrumab: What do They Mean for Clinical Practice?
por: Ryan, Donna H.
Publicado: (2021)

Influence of Exercise on the Metabolic Profile Caused by 28 days of Bed Rest with Energy Deficit and Amino Acid Supplementation in Healthy Men
por: Brooks, Naomi E., et al.
Publicado: (2014)

Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults
por: Bharadwaj, Manish S., et al.
Publicado: (2015)

Who Works Among Older Black and White, Well-Functioning Adults in the Health, Aging, and Body Composition Study?
por: Rooks, Ronica N., et al.
Publicado: (2017)

Randomized, Open-Label Study of the Pharmacokinetics and Safety of Oral and Intravenous Administration of Omadacycline to Healthy Subjects
por: Sun, Haiying, et al.
Publicado: (2016)

OR10-03 Murine Bimagrumab Co-administration With Incretin Agonists Results In Additive Efficacy And Superior Quality Weight Loss In The Mouse Diet-induced Obesity Model
por: Nguyen, Kevin, et al.
Publicado: (2023)

RF28 | PSUN198 The Dramatic Fat Mass Loss Caused by Bimagrumab is Similar in Diabetic and Non-diabetic Patients.
por: Klickstein, Lloyd, et al.
Publicado: (2022)

The Association of Meal Timing With Body Composition and Cardiometabolic Health in Obese Older Adults
por: Farsijani, Samaneh, et al.
Publicado: (2021)

Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis
por: Chiang, En-Pei I, et al.
Publicado: (2005)

Gentrification and Chronic Conditions in Older Adults: Service Providers’ Perspectives
por: Rooks, Ronica
Publicado: (2020)

Inflammation causes tissue-specific depletion of vitamin B(6)
por: Chiang, En-Pei, et al.
Publicado: (2005)

Body composition and functional performance of older adults
por: Paranhos Amorim, Diane Nogueira, et al.
Publicado: (2022)

Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers
por: Family, Neiloufar, et al.
Publicado: (2019)

Effect of Exercise Type during Intentional Weight Loss on Body Composition in Older Adults with Obesity
por: Beavers, Kristen M., et al.
Publicado: (2017)

Effects of water exercise on body composition and components of metabolic syndrome in older females with sarcopenic obesity
por: Qi, Shumeng, et al.
Publicado: (2023)

An Open-Label Study of the Impact of Hepatic Impairment on the Pharmacokinetics and Safety of Single Oral and Intravenous Doses of Omadacycline
por: Kovacs, Steven J., et al.
Publicado: (2020)

A Phase 1 study for safety and pharmacokinetics of BIO101 (20‐hydroxyecdysone) in healthy young and older adults
por: Dioh, Waly, et al.
Publicado: (2023)

MON-098 FSH and Body Composition in Older Adults
por: Woods, Gina, et al.
Publicado: (2019)

Associations of Body Composition and Mitochondrial Function in Older Adults
por: Cawthon, Peggy, et al.
Publicado: (2021)

Effects of smartphone mirroring-based telepresence exercise on body composition and physical function in obese older women
por: Hong, Jeeyoung, et al.
Publicado: (2022)

ASPIRIN BENEFIT IS NOT AFFECTED BY BODY WEIGHT IN HEALTHY OLDER PERSONS
por: Woods, Robyn L, et al.
Publicado: (2019)

Neighborhood Environment and Self-Rated Health Among Urban Older Adults
por: Mathis, Arlesia, et al.
Publicado: (2015)

Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly
por: Brzeszczyńska, Joanna, et al.
Publicado: (2016)

Use of Health Information Varies by Region Among Older Adults in the U.S.
por: Mathis, Arlesia, et al.
Publicado: (2021)

Pharmacokinetic Considerations for Digoxin in Older People
por: Currie, Geoffrey M, et al.
Publicado: (2011)

Effect of an 18 month physical activity and weight loss intervention on body composition in overweight and obese older adults
por: Beavers, Kristen M., et al.
Publicado: (2013)

The Combined Effects of Tai Chi, Resistance Training, and Diet on Physical Function and Body Composition in Obese Older Women
por: Maris, S. A., et al.
Publicado: (2014)

Differences in Body Composition in Older People from Two Regions of Mexico: Implications for Diagnoses of Sarcopenia and Sarcopenic Obesity
por: Rangel Peniche, Diana Beatriz, et al.
Publicado: (2018)

Body Composition and Physical Function in Older Adults with Various Comorbidities
por: Kim, Sunghye, et al.
Publicado: (2017)

A dataset on body composition, strength and performance in older adults
por: RoyChoudhury, Arindam, et al.
Publicado: (2020)

Body Composition Characteristics of Community-Dwelling Older Adults With Dynapenia
por: Jung, Hungu, et al.
Publicado: (2022)

The Use of Practical Measures to Determine Body Composition of Older People
por: Chokphukiao, Pakwipa, et al.
Publicado: (2023)

Improving the Neighborhood Environment for Urban Older Adults: Social Context and Self-Rated Health
por: Mathis, Arlesia, et al.
Publicado: (2015)

Tai Chi for treating knee osteoarthritis: Designing a long-term follow up randomized controlled trial
por: Wang, Chenchen, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_62ilogn3vcc3f9l8aaas52qma4