Understanding the characteristics of nonspecific binding of drug-like compounds to canonical stem–loop RNAs and their implications for functional cellular assays

Identifying small molecules that selectively bind an RNA target while discriminating against all other cellular RNAs is an important challenge in RNA-targeted drug discovery. Much effort has been directed toward identifying drug-like small molecules that minimize electrostatic and stacking interacti...

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Detalles Bibliográficos
Autores principales: Kelly, Megan L., Chu, Chia-Chieh, Shi, Honglue, Ganser, Laura R., Bogerd, Hal P., Huynh, Kelly, Hou, Yuze, Cullen, Bryan R., Al-Hashimi, Hashim M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749633/
https://www.ncbi.nlm.nih.gov/pubmed/33028652
http://dx.doi.org/10.1261/rna.076257.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749633/
https://www.ncbi.nlm.nih.gov/pubmed/33028652
http://dx.doi.org/10.1261/rna.076257.120

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