Cargando…

Inhibition of tumor suppressor p73 by nerve growth factor receptor via chaperone-mediated autophagy

The tumor suppressr p73 is a homolog of p53 and is capable of inducing cell cycle arrest and apoptosis. Here, we identify nerve growth factor receptor (NGFR, p75NTR, or CD271) as a novel negative p73 regulator. p73 activates NGFR transcription, which, in turn, promotes p73 degradation in a negative...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Daniel, Yang, Kun, Chiao, Lucia, Deng, Yun, Zhou, Xiang, Zhang, Zhen, Zeng, Shelya X, Lu, Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749740/ https://www.ncbi.nlm.nih.gov/pubmed/32285119 http://dx.doi.org/10.1093/jmcb/mjaa017

Ejemplares similares

Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator
por: Zhou, Xiang, et al.
Publicado: (2016)

Inactivating p53 is essential for nerve growth factor receptor to promote melanoma-initiating cell-stemmed tumorigenesis
por: Jiang, Leiwei, et al.
Publicado: (2020)

Inhibition of chaperone-mediated autophagy reduces tumor growth and metastasis and promotes drug sensitivity in colorectal cancer
por: Xuan, Ying, et al.
Publicado: (2021)

73. Increasing Survival of Transplanted Fat Using Endothelial Chaperones
por: Salazar, Hector F., et al.
Publicado: (2023)

Structure and Activity Analysis of Inauhzin Analogs as Novel Antitumor Compounds That Induce p53 and Inhibit Cell Growth
por: Zhang, Qi, et al.
Publicado: (2012)

Chaperone-mediated autophagy substrate proteins in cancer
por: Tang, Ying, et al.
Publicado: (2017)

Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity
por: Mannini, Benedetta, et al.
Publicado: (2017)

Global Effect of Inauhzin on Human p53-Responsive Transcriptome
por: Liao, Jun-Ming, et al.
Publicado: (2012)

Some facts and thoughts: p73 as a tumor suppressor gene in the network of tumor suppressors
por: Boominathan, Lakshmanane
Publicado: (2007)

Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53
por: Chao, Tengfei, et al.
Publicado: (2016)

Determination of maximum tolerated dose and toxicity of Inauhzin in mice
por: Zhang, Qi, et al.
Publicado: (2015)

Deficient Chaperone-Mediated Autophagy Promotes Lipid Accumulation in Macrophage
por: Qiao, Lei, et al.
Publicado: (2020)

p73α1, an Isoform of the p73 Tumor Suppressor, Modulates Lipid Metabolism and Cancer Cell Growth via Stearoyl-CoA Desaturase-1
por: Rabow, Zachary, et al.
Publicado: (2022)

Structural Basis for ASPP2 Recognition by the Tumor Suppressor p73
por: Canning, Peter, et al.
Publicado: (2012)

The Complex Role of Chaperone-Mediated Autophagy in Cancer Diseases
por: Liu, Jing, et al.
Publicado: (2023)

A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
por: Zhang, Qi, et al.
Publicado: (2012)

Chaperone-mediated autophagy: roles in neurodegeneration
por: Wang, Gang, et al.
Publicado: (2014)

The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress
por: Zhang, Qi, et al.
Publicado: (2014)

Proinflammatory Cytokines and Bile Acids Upregulate ΔNp73 Protein, an Inhibitor of p53 and p73 Tumor Suppressors
por: Zaika, Elena, et al.
Publicado: (2013)

UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer
por: Xiang, Gang, et al.
Publicado: (2022)

Deficient Chaperone-Mediated Autophagy Promotes Inflammation and Atherosclerosis
por: Qiao, Lei, et al.
Publicado: (2021)

It takes a team: a gain-of-function story of p53-R249S
por: Wang, Huai, et al.
Publicado: (2019)

New Insights into the Mechanisms of Chaperon-Mediated Autophagy and Implications for Kidney Diseases
por: Yuan, Zhen, et al.
Publicado: (2022)

Ribosomopathies: Mechanisms of Disease
por: Nakhoul, Hani, et al.
Publicado: (2014)

Interplay of LRRK2 with chaperone-mediated autophagy
por: Orenstein, Samantha J., et al.
Publicado: (2013)

The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation
por: Qi, Lin, et al.
Publicado: (2012)

Tension-induced autophagy: May the chaperone be with you
por: Ulbricht, Anna, et al.
Publicado: (2013)

Humanin is an endogenous activator of chaperone-mediated autophagy
por: Gong, Zhenwei, et al.
Publicado: (2018)

Chaperone-Mediated Autophagy in the Liver: Good or Bad?
por: Dash, Srikanta, et al.
Publicado: (2019)

Chaperone Mediated Autophagy Substrates and Components in Cancer
por: Rios, Javiera, et al.
Publicado: (2021)

Chaperone-mediated autophagy protects against atherosclerosis
por: Madrigal-Matute, Julio, et al.
Publicado: (2022)

Chaperone-mediated autophagy regulates adipocyte differentiation
por: Kaushik, Susmita, et al.
Publicado: (2022)

The Role of Chaperone-Mediated Autophagy in Hepatitis C Virus-Induced Pathogenesis
por: Matsui, Chieko, et al.
Publicado: (2021)

XPD Functions as a Tumor Suppressor and Dysregulates Autophagy in Cultured HepG2 Cells
por: Zheng, Jian-feng, et al.
Publicado: (2015)

RBM10, a New Regulator of p53
por: Jung, Ji Hoon, et al.
Publicado: (2020)

Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF
por: Lo, Dorothy, et al.
Publicado: (2014)

Pincher, a pinocytic chaperone for nerve growth factor/TrkA signaling endosomes
por: Shao, Yufang, et al.
Publicado: (2002)

Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73
por: Huang, Vera, et al.
Publicado: (2009)

MCL1 binds and negatively regulates the transcriptional function of tumor suppressor p73
por: Widden, Hayley, et al.
Publicado: (2020)

Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy
por: Wu, Jia-Zhen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ico4652u5og281rqnrsa2h297i