A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I

Guanosine triphosphate (GTP) cyclohydrolase I (GCH1) catalyzes the conversion of GTP to dihydroneopterin triphosphate (H2NTP), the initiating step in the biosynthesis of tetrahydrobiopterin (BH4). Besides other roles, BH4 functions as cofactor in neurotransmitter biosynthesis. The BH4 biosynthetic p...

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Detalles Bibliográficos
Autores principales: Ebenhoch, Rebecca, Prinz, Simone, Kaltwasser, Susann, Mills, Deryck J., Meinecke, Robert, Rübbelke, Martin, Reinert, Dirk, Bauer, Margit, Weixler, Lisa, Zeeb, Markus, Vonck, Janet, Nar, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750480/
https://www.ncbi.nlm.nih.gov/pubmed/33229582
http://dx.doi.org/10.1073/pnas.2013473117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750480/
https://www.ncbi.nlm.nih.gov/pubmed/33229582
http://dx.doi.org/10.1073/pnas.2013473117

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