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A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I
Guanosine triphosphate (GTP) cyclohydrolase I (GCH1) catalyzes the conversion of GTP to dihydroneopterin triphosphate (H2NTP), the initiating step in the biosynthesis of tetrahydrobiopterin (BH4). Besides other roles, BH4 functions as cofactor in neurotransmitter biosynthesis. The BH4 biosynthetic p...
Autores principales: | Ebenhoch, Rebecca, Prinz, Simone, Kaltwasser, Susann, Mills, Deryck J., Meinecke, Robert, Rübbelke, Martin, Reinert, Dirk, Bauer, Margit, Weixler, Lisa, Zeeb, Markus, Vonck, Janet, Nar, Herbert |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750480/ https://www.ncbi.nlm.nih.gov/pubmed/33229582 http://dx.doi.org/10.1073/pnas.2013473117 |
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