Cargando…

Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study

BACKGROUND: Gastro-oesophageal reflux disease (GORD) is associated with multiple risk factors but determining causality is difficult. We used a genetic approach [Mendelian randomization (MR)] to identify potential causal modifiable risk factors for GORD. METHODS: We used data from 451 097 European p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Green, Harry D, Beaumont, Robin N, Wood, Andrew R, Hamilton, Benjamin, Jones, Samuel E, Goodhand, James R, Kennedy, Nicholas A, Ahmad, Tariq, Yaghootkar, Hanieh, Weedon, Michael N, Frayling, Timothy M, Tyrrell, Jessica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Mendelian Randomization
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750946/ https://www.ncbi.nlm.nih.gov/pubmed/32588049 http://dx.doi.org/10.1093/ije/dyaa082

Ejemplares similares

Using genetics to understand the causal influence of higher BMI on depression
por: Tyrrell, Jessica, et al.
Publicado: (2019)

Effects of body mass index on relationship status, social contact and socio-economic position: Mendelian randomization and within-sibling study in UK Biobank
por: Howe, Laura D, et al.
Publicado: (2019)

Factorial Mendelian randomization: using genetic variants to assess interactions
por: Rees, Jessica M B, et al.
Publicado: (2019)

Contextualizing selection bias in Mendelian randomization: how bad is it likely to be?
por: Gkatzionis, Apostolos, et al.
Publicado: (2019)

Selecting instruments for Mendelian randomization in the wake of genome-wide association studies
por: Swerdlow, Daniel I, et al.
Publicado: (2016)

Empirical comparisons of multiple Mendelian randomization approaches in the presence of assortative mating
por: Minică, Camelia C, et al.
Publicado: (2020)

The causal effects of serum lipids and apolipoproteins on kidney function: multivariable and bidirectional Mendelian-randomization analyses
por: Rasheed, Humaira, et al.
Publicado: (2021)

Detecting and correcting for bias in Mendelian randomization analyses using Gene-by-Environment interactions
por: Spiller, Wes, et al.
Publicado: (2019)

The relationship between sleep duration, cognition and dementia: a Mendelian randomization study
por: Henry, Albert, et al.
Publicado: (2019)

Repurposing antihypertensive drugs for the prevention of Alzheimer’s disease: a Mendelian randomization study
por: Walker, Venexia M, et al.
Publicado: (2019)

The contribution of tissue-grouped BMI-associated gene sets to cardiometabolic-disease risk: a Mendelian randomization study
por: Verkouter, Inge, et al.
Publicado: (2020)

An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings
por: Sanderson, Eleanor, et al.
Publicado: (2019)

Phenome-wide Mendelian-randomization study of genetically determined vitamin D on multiple health outcomes using the UK Biobank study
por: Meng, Xiangrui, et al.
Publicado: (2019)

Commentary: One size fits all: are there standard rules for the use of genetic instruments in Mendelian randomization?
por: Timpson, Nicholas J
Publicado: (2016)

Improving the accuracy of two-sample summary-data Mendelian randomization: moving beyond the NOME assumption
por: Bowden, Jack, et al.
Publicado: (2019)

Cleft lip/palate and educational attainment: cause, consequence or correlation? A Mendelian randomization study
por: Dardani, Christina, et al.
Publicado: (2020)

Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease
por: Zheng, Jie, et al.
Publicado: (2021)

Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization
por: Evans, David M, et al.
Publicado: (2019)

Education, intelligence and Alzheimer’s disease: evidence from a multivariable two-sample Mendelian randomization study
por: Anderson, Emma L, et al.
Publicado: (2020)

Evaluating the direct effects of childhood adiposity on adult systemic metabolism: a multivariable Mendelian randomization analysis
por: Richardson, Tom G, et al.
Publicado: (2021)

Commentary: Mendelian randomization analysis identifies circulating vitamin D as a causal risk factor for ovarian cancer
por: Bull, Caroline J, et al.
Publicado: (2016)

Education protects against coronary heart disease and stroke independently of cognitive function: evidence from Mendelian randomization
por: Gill, Dipender, et al.
Publicado: (2019)

The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis
por: Ooi, Brandon Nick Sern, et al.
Publicado: (2019)

Assessing causal links between metabolic traits, inflammation and schizophrenia: a univariable and multivariable, bidirectional Mendelian-randomization study
por: Lin, Bochao D, et al.
Publicado: (2019)

Inference about causation from examination of familial confounding (ICE FALCON): a model for assessing causation analogous to Mendelian randomization
por: Li, Shuai, et al.
Publicado: (2020)

Using Mendelian randomization to investigate a possible causal relationship between adiposity and increased bone mineral density at different skeletal sites in children
por: Kemp, John P, et al.
Publicado: (2016)

Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight
por: Hwang, Liang-Dar, et al.
Publicado: (2019)

Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health
por: Yang, Qian, et al.
Publicado: (2019)

Association of lactase persistence genotype with milk consumption, obesity and blood pressure: a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort, with a systematic review and meta-analysis
por: Hartwig, Fernando Pires, et al.
Publicado: (2016)

Appraising the causal relevance of DNA methylation for risk of lung cancer
por: Battram, Thomas, et al.
Publicado: (2019)

A phenome-wide association study of a lipoprotein-associated phospholipase A(2) loss-of-function variant in 90 000 Chinese adults
por: Millwood, Iona Y, et al.
Publicado: (2016)

An integrative approach to detect epigenetic mechanisms that putatively mediate the influence of lifestyle exposures on disease susceptibility
por: Richardson, Tom G, et al.
Publicado: (2019)

Commentary: Causal associations between inflammation, cardiometabolic markers and schizophrenia: the known unknowns
por: Khandaker, Golam M
Publicado: (2019)

Commentary: CRP and schizophrenia: cause, consequence or confounding?
por: Ligthart, Symen
Publicado: (2019)

Is genetic liability to ADHD and ASD causally linked to educational attainment?
por: Dardani, Christina, et al.
Publicado: (2021)

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
por: Bowden, Jack, et al.
Publicado: (2015)

Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways
por: Burgess, Stephen, et al.
Publicado: (2015)

Higher adiposity and mental health: causal inference using Mendelian randomization
por: Casanova, Francesco, et al.
Publicado: (2021)

Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank
por: Tyrrell, Jessica, et al.
Publicado: (2016)

Gastro-oesophageal reflux disease and eosinophilic oesophagitis: What is the relationship?
por: Wong, Stephanie, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_fkhdahd651qhctt51v0700eek8