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Solubility-Weighted Index: fast and accurate prediction of protein solubility

MOTIVATION: Recombinant protein production is a widely used technique in the biotechnology and biomedical industries, yet only a quarter of target proteins are soluble and can therefore be purified. RESULTS: We have discovered that global structural flexibility, which can be modeled by normalized B-...

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Detalles Bibliográficos
Autores principales: Bhandari, Bikash K, Gardner, Paul P, Lim, Chun Shen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750957/
https://www.ncbi.nlm.nih.gov/pubmed/32559287
http://dx.doi.org/10.1093/bioinformatics/btaa578