Predicting substitutions to modulate disorder and stability in coiled-coils

BACKGROUND: Coiled-coils are described as stable structural motifs, where two or more helices wind around each other. However, coiled-coils are associated with local mobility and intrinsic disorder. Intrinsically disordered regions in proteins are characterized by lack of stable secondary and tertia...

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Detalles Bibliográficos
Autores principales: Karami, Yasaman, Saighi, Paul, Vanderhaegen, Rémy, Gerlier, Denis, Longhi, Sonia, Laine, Elodie, Carbone, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751101/
https://www.ncbi.nlm.nih.gov/pubmed/33349244
http://dx.doi.org/10.1186/s12859-020-03867-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751101/
https://www.ncbi.nlm.nih.gov/pubmed/33349244
http://dx.doi.org/10.1186/s12859-020-03867-x

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