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Hypoxic exposure activates the B cell-specific Moloney murine leukaemia virus integration site 1/PI3K/Akt axis and promotes EMT in leukaemia stem cells

Acute myeloid leukemia (AML) is a malignant tumor of the immature myeloid hematopoietic cells in the bone marrow. Disease recurrence driven by leukaemia stem cells (LSCs), a sub-population of leukaemia cells presenting self-renewal capacity and differentiation potential, is a major problem in the tr...

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Detalles Bibliográficos
Autores principales: Jiang, Mingyan, He, Guoqian, Li, Jianhua, Li, Jinrong, Guo, Xia, Gao, Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751341/
https://www.ncbi.nlm.nih.gov/pubmed/33376531
http://dx.doi.org/10.3892/ol.2020.12359