Cargando…

4-Octyl Itaconate Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting Oxidative Stress and Inflammation

BACKGROUND: Acute lung injury (ALI) is a fatal disease in the absence of pharmacological treatment. Oxidative stress and inflammation are closely related to ALI. Innate immune cells are the main source of reactive oxygen species (ROS). Macrophages play an extremely important role in ALI through the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yang, Chen, Xing, Zhang, Hua, Xiao, Jie, Yang, Chuanlei, Chen, Weiqiang, Wei, Zhanjie, Chen, Xinzhong, Liu, Jinping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751705/ https://www.ncbi.nlm.nih.gov/pubmed/33364751 http://dx.doi.org/10.2147/DDDT.S280922

Ejemplares similares

4‐octyl Itaconate inhibits lipopolysaccharide (LPS)‐induced osteoarthritis via activating Nrf2 signalling pathway
por: Zhang, Qingchen, et al.
Publicado: (2022)

Four-octyl itaconate activates Nrf2 cascade to protect osteoblasts from hydrogen peroxide-induced oxidative injury
por: Zheng, Yuehuan, et al.
Publicado: (2020)

The Cell-Permeable Derivative of the Immunoregulatory Metabolite Itaconate, 4-Octyl Itaconate, Is Anti-Fibrotic in Systemic Sclerosis
por: Henderson, John, et al.
Publicado: (2021)

Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis
por: Yang, Wenchang, et al.
Publicado: (2022)

4-Octyl itaconate (4-OI) attenuates lipopolysaccharide-induced acute lung injury by suppressing PI3K/Akt/NF-κB signaling pathways in mice
por: Xin, Yan, et al.
Publicado: (2021)

Four-Octyl itaconate ameliorates periodontal destruction via Nrf2-dependent antioxidant system
por: Xin, Liangjing, et al.
Publicado: (2022)

Protective Role of 4-Octyl Itaconate in Murine LPS/D-GalN-Induced Acute Liver Failure via Inhibiting Inflammation, Oxidative Stress, and Apoptosis
por: Li, Ruidong, et al.
Publicado: (2021)

Mechanisms underlying the therapeutic effects of 4-octyl itaconate in treating sepsis based on network pharmacology and molecular docking
por: Chen, Maolin, et al.
Publicado: (2022)

Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide
por: Liu, Hua, et al.
Publicado: (2018)

4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling
por: Xu, Lujun, et al.
Publicado: (2023)

Modulating Neuro-Immune-Induced Macrophage Polarization With Topiramate Attenuates Experimental Abdominal Aortic Aneurysm
por: Chen, Xing, et al.
Publicado: (2020)

4-Octyl-itaconate and dimethyl fumarate inhibit COX2 expression and prostaglandin production in macrophages
por: Diskin, Ciana, et al.
Publicado: (2021)

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
por: Liao, Shan-Ting, et al.
Publicado: (2019)

Four-Octyl Itaconate Attenuates UVB-Induced Melanocytes and Keratinocytes Apoptosis by Nrf2 Activation-Dependent ROS Inhibition
por: Xie, Yongyi, et al.
Publicado: (2022)

Dimethyl itaconate alleviates the pyroptosis of macrophages through oxidative stress
por: Huang, Shan-Shan, et al.
Publicado: (2021)

The signaling pathways and therapeutic potential of itaconate to alleviate inflammation and oxidative stress in inflammatory diseases
por: Shi, Xuan, et al.
Publicado: (2022)

4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1
por: Ribó-Molina, Pau, et al.
Publicado: (2023)

All-trans retinoic acid attenuates the progression of Ang II-induced abdominal aortic aneurysms in ApoE(−/−)mice
por: Xiao, Jie, et al.
Publicado: (2020)

Four-Octyl Itaconate Protects Chondrocytes against H(2)O(2)-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling
por: Zhang, Peng, et al.
Publicado: (2022)

Itaconic Acid Based Surfactants: I. Synthesis and Characterization of Sodium n-Octyl Sulfoitaconate Diester Anionic Surfactant
por: Xu, Jun, et al.
Publicado: (2016)

4-Octyl itaconate attenuates glycemic deterioration by regulating macrophage polarization in mouse models of type 1 diabetes
por: He, Sunyue, et al.
Publicado: (2023)

Microglia-dependent neuroprotective effects of 4-octyl itaconate against rotenone-and MPP+-induced neurotoxicity in Parkinson’s disease
por: Xia, Ning, et al.
Publicado: (2023)

4‐octyl itaconate improves the viability of D66H cells by regulating the KEAP1‐NRF2‐GCLC/HO‐1 pathway
por: Chen, Yanrui, et al.
Publicado: (2023)

Eupatilin Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammation and Oxidative Stress
por: Liu, Haiying, et al.
Publicado: (2019)

Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
por: Ryan, Tristram A. J., et al.
Publicado: (2023)

Icariin Alleviates Escherichia coli Lipopolysaccharide-Mediated Endometritis in Mice by Inhibiting Inflammation and Oxidative Stress
por: Shaukat, Aftab, et al.
Publicado: (2022)

Four-octyl itaconate improves osteoarthritis by enhancing autophagy in chondrocytes via PI3K/AKT/mTOR signalling pathway inhibition
por: Pan, Xuekang, et al.
Publicado: (2022)

4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2
por: Diskin, Ciana, et al.
Publicado: (2023)

IRG1/itaconate increases IL-10 release to alleviate mechanical and thermal hypersensitivity in mice after nerve injury
por: Sun, Qingyu, et al.
Publicado: (2022)

4-Octyl itaconate regulates immune balance by activating Nrf2 and negatively regulating PD-L1 in a mouse model of sepsis
por: Zhang, Peng, et al.
Publicado: (2022)

Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
por: Ryan, Tristram A. J., et al.
Publicado: (2023)

Itaconate: A Metabolite Regulates Inflammation Response and Oxidative Stress
por: Li, Ruidong, et al.
Publicado: (2020)

The role of itaconate in host defense and inflammation
por: Peace, Christian G., et al.
Publicado: (2022)

4-Octyl Itaconate Prevents Free Fatty Acid-Induced Lipid Metabolism Disorder through Activating Nrf2-AMPK Signaling Pathway in Hepatocytes
por: Chu, Xu, et al.
Publicado: (2022)

The potential of using itaconate as treatment for inflammation-related heart diseases
por: Ku, Hui-Chen, et al.
Publicado: (2021)

Melatonin alleviates lipopolysaccharide-induced myocardial injury by inhibiting inflammation and pyroptosis in cardiomyocytes
por: Su, Ze-Da-Zhong, et al.
Publicado: (2021)

Alanyl-Glutamine Protects against Lipopolysaccharide-Induced Liver Injury in Mice via Alleviating Oxidative Stress, Inhibiting Inflammation, and Regulating Autophagy
por: Hu, Jiaji, et al.
Publicado: (2022)

Itaconate Suppresses the Activation of Mitochondrial NLRP3 Inflammasome and Oxidative Stress in Allergic Airway Inflammation
por: Xie, Qiu-Meng, et al.
Publicado: (2023)

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
por: Olagnier, David, et al.
Publicado: (2020)

Itaconate Isomers in Bread
por: Gruenwald, Mona, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3qnmncldbadrfu3tfmsikji3kv