Limited expression of non-integrating CpG-free plasmid is associated with increased nucleosome enrichment

CpG-free pDNA was reported to facilitate sustained transgene expression with minimal inflammation in vivo as compared to CpG-containing pDNA. However, the expression potential and impact of CpG-free pDNA in in vitro model have never been described. Hence, in this study, we analyzed the transgene exp...

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Detalles Bibliográficos
Autores principales: Habib, Omar, Mohd Sakri, Rozita, Ghazalli, Nadiah, Chau, De-Ming, Ling, King-Hwa, Abdullah, Syahril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751972/
https://www.ncbi.nlm.nih.gov/pubmed/33347482
http://dx.doi.org/10.1371/journal.pone.0244386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751972/
https://www.ncbi.nlm.nih.gov/pubmed/33347482
http://dx.doi.org/10.1371/journal.pone.0244386

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