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Limited expression of non-integrating CpG-free plasmid is associated with increased nucleosome enrichment
CpG-free pDNA was reported to facilitate sustained transgene expression with minimal inflammation in vivo as compared to CpG-containing pDNA. However, the expression potential and impact of CpG-free pDNA in in vitro model have never been described. Hence, in this study, we analyzed the transgene exp...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751972/ https://www.ncbi.nlm.nih.gov/pubmed/33347482 http://dx.doi.org/10.1371/journal.pone.0244386 |