Knockdown of lactate dehydrogenase by adeno‐associated virus‐delivered CRISPR/Cas9 system alleviates primary hyperoxaluria type 1

BACKGROUND: Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder caused by endogenous overproduction of hepatic oxalate, leading to hyperoxaluria, recurrent calcium oxalate kidney stones, and end‐stage renal disease. Lactate dehydrogenase (LDH) is an ideal target for diminishing oxalate pro...

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Detalles Bibliográficos
Autores principales: Zheng, Rui, Fang, Xiaoliang, Chen, Xi, Huang, Yunteng, Xu, Guofeng, He, Lei, Li, Yueyan, Niu, Xuran, Yang, Lei, Wang, Liren, Li, Dali, Geng, Hongquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752156/
https://www.ncbi.nlm.nih.gov/pubmed/33377632
http://dx.doi.org/10.1002/ctm2.261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752156/
https://www.ncbi.nlm.nih.gov/pubmed/33377632
http://dx.doi.org/10.1002/ctm2.261

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