Cytoplasmic Expression of the ALS/FTD-Related Protein TDP-43 Decreases Global Translation Both in vitro and in vivo

TDP-43 is a major component of cytoplasmic inclusions observed in neurodegenerative diseases like frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). To further understand the role of TDP-43 in mRNA/protein metabolism and proteostasis, we used a combined approach with cellular and...

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Detalles Bibliográficos
Autores principales: Charif, Santiago E., Luchelli, Luciana, Vila, Antonella, Blaustein, Matías, Igaz, Lionel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752804/
https://www.ncbi.nlm.nih.gov/pubmed/33363456
http://dx.doi.org/10.3389/fncel.2020.594561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752804/
https://www.ncbi.nlm.nih.gov/pubmed/33363456
http://dx.doi.org/10.3389/fncel.2020.594561

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