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Cytoplasmic Expression of the ALS/FTD-Related Protein TDP-43 Decreases Global Translation Both in vitro and in vivo

TDP-43 is a major component of cytoplasmic inclusions observed in neurodegenerative diseases like frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). To further understand the role of TDP-43 in mRNA/protein metabolism and proteostasis, we used a combined approach with cellular and...

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Detalles Bibliográficos
Autores principales:	Charif, Santiago E., Luchelli, Luciana, Vila, Antonella, Blaustein, Matías, Igaz, Lionel M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752804/ https://www.ncbi.nlm.nih.gov/pubmed/33363456 http://dx.doi.org/10.3389/fncel.2020.594561

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