Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase

Human NAD-dependent isocitrate dehydrogenase or HsIDH3 catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the TCA cycle. HsIDH3 exists and functions as a heterooctamer composed of the αβ and αγ heterodimers, and is regulated allosterically and/or competitively by numerous metabolite...

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Detalles Bibliográficos
Autores principales: Sun, Pengkai, Liu, Yan, Ma, Tengfei, Ding, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752914/
https://www.ncbi.nlm.nih.gov/pubmed/33349631
http://dx.doi.org/10.1038/s41421-020-00220-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752914/
https://www.ncbi.nlm.nih.gov/pubmed/33349631
http://dx.doi.org/10.1038/s41421-020-00220-7

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