The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness

Wnt/β-catenin signaling is crucial for intestinal carcinogenesis and the maintenance of intestinal cancer stem cells. Here we identify the histone methyltransferase Mll1 as a regulator of Wnt-driven intestinal cancer. Mll1 is highly expressed in Lgr5(+) stem cells and human colon carcinomas with inc...

Descripción completa

Detalles Bibliográficos
Autores principales: Grinat, Johanna, Heuberger, Julian, Vidal, Ramon Oliveira, Goveas, Neha, Kosel, Frauke, Berenguer-Llergo, Antoni, Kranz, Andrea, Wulf-Goldenberg, Annika, Behrens, Diana, Melcher, Bálint, Sauer, Sascha, Vieth, Michael, Batlle, Eduard, Stewart, A. Francis, Birchmeier, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752919/
https://www.ncbi.nlm.nih.gov/pubmed/33349639
http://dx.doi.org/10.1038/s41467-020-20222-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752919/
https://www.ncbi.nlm.nih.gov/pubmed/33349639
http://dx.doi.org/10.1038/s41467-020-20222-z

Ejemplares similares