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The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness

Wnt/β-catenin signaling is crucial for intestinal carcinogenesis and the maintenance of intestinal cancer stem cells. Here we identify the histone methyltransferase Mll1 as a regulator of Wnt-driven intestinal cancer. Mll1 is highly expressed in Lgr5(+) stem cells and human colon carcinomas with inc...

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Detalles Bibliográficos
Autores principales:	Grinat, Johanna, Heuberger, Julian, Vidal, Ramon Oliveira, Goveas, Neha, Kosel, Frauke, Berenguer-Llergo, Antoni, Kranz, Andrea, Wulf-Goldenberg, Annika, Behrens, Diana, Melcher, Bálint, Sauer, Sascha, Vieth, Michael, Batlle, Eduard, Stewart, A. Francis, Birchmeier, Walter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752919/ https://www.ncbi.nlm.nih.gov/pubmed/33349639 http://dx.doi.org/10.1038/s41467-020-20222-z

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