Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1

Myotonic Dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by toxic DMPK transcripts that carry CUG repeat expansions in the 3′ untranslated region (3′UTR). The intrinsic complexity and lack of crystallographic data makes noncoding RNA regions challenging targets to study in the f...

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Detalles Bibliográficos
Autores principales: Ondono, Raul, Lirio, Ángel, Elvira, Carlos, Álvarez-Marimon, Elena, Provenzano, Claudia, Cardinali, Beatrice, Pérez-Alonso, Manuel, Perálvarez-Marín, Alex, Borrell, José I., Falcone, Germana, Estrada-Tejedor, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753043/
https://www.ncbi.nlm.nih.gov/pubmed/33363709
http://dx.doi.org/10.1016/j.csbj.2020.11.053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753043/
https://www.ncbi.nlm.nih.gov/pubmed/33363709
http://dx.doi.org/10.1016/j.csbj.2020.11.053

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