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Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1
Myotonic Dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by toxic DMPK transcripts that carry CUG repeat expansions in the 3′ untranslated region (3′UTR). The intrinsic complexity and lack of crystallographic data makes noncoding RNA regions challenging targets to study in the f...
Autores principales: | Ondono, Raul, Lirio, Ángel, Elvira, Carlos, Álvarez-Marimon, Elena, Provenzano, Claudia, Cardinali, Beatrice, Pérez-Alonso, Manuel, Perálvarez-Marín, Alex, Borrell, José I., Falcone, Germana, Estrada-Tejedor, Roger |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753043/ https://www.ncbi.nlm.nih.gov/pubmed/33363709 http://dx.doi.org/10.1016/j.csbj.2020.11.053 |
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