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In silico and in vitro insights into tyrosinase inhibitors with a 2-thioxooxazoline-4-one template

The β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold confers tyrosinase inhibitory activity, and in the present study, 16 (Z)-5-(substituted benzylidene)-3-phenyl-2-thioxooxazolidin-4-one analogues containing this scaffold were synthesized. Mushroom tyrosinase inhibitory activities were examined. C...

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Detalles Bibliográficos
Autores principales: Choi, Inkyu, Park, Yujin, Ryu, Il Young, Jung, Hee Jin, Ullah, Sultan, Choi, Heejeong, Park, Chaeun, Kang, Dongwan, Lee, Sanggwon, Chun, Pusoon, Young Chung, Hae, Moon, Hyung Ryong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753086/
https://www.ncbi.nlm.nih.gov/pubmed/33363708
http://dx.doi.org/10.1016/j.csbj.2020.12.001