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High-throughput determination of protein affinities using unmodified peptide libraries in nanomolar scale

Protein-protein interactions (PPIs) are of fundamental importance for our understanding of physiology and pathology. PPIs involving short, linear motifs play a major role in immunological recognition, signaling, and regulation and provide attractive starting points for pharmaceutical intervention. Y...

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Detalles Bibliográficos
Autores principales: Schulte, Clemens, Khayenko, Vladimir, Nordblom, Noah Frieder, Tippel, Franziska, Peck, Violetta, Gupta, Amit Jean, Maric, Hans Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753147/
https://www.ncbi.nlm.nih.gov/pubmed/33364586
http://dx.doi.org/10.1016/j.isci.2020.101898