Identification of Small Molecule Inhibitors of the Deubiquitinating Activity of the SARS-CoV-2 Papain-Like Protease: in silico Molecular Docking Studies and in vitro Enzymatic Activity Assay

COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 virus with important political, socio-economic, and public health consequences. Inhibiting replication represents an important antiviral approach, and in this context two viral proteases, the SARS-CoV-2 main and papain-like proteases (PL(pro))...

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Detalles Bibliográficos
Autores principales: Pitsillou, Eleni, Liang, Julia, Ververis, Katherine, Lim, Kah Wai, Hung, Andrew, Karagiannis, Tom C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753156/
https://www.ncbi.nlm.nih.gov/pubmed/33364229
http://dx.doi.org/10.3389/fchem.2020.623971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753156/
https://www.ncbi.nlm.nih.gov/pubmed/33364229
http://dx.doi.org/10.3389/fchem.2020.623971

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