Blockade of spinal dopamine D1/D2 receptor suppresses activation of NMDA receptor through Gαq and Src kinase to attenuate chronic bone cancer pain

INTRODUCTION: Spinal N-methyl-D-aspartate receptor (NMDAR) is vital in chronic pain, while NMDAR antagonists have severe side effects. NMDAR has been reported to be controlled by G protein coupled receptors (GPCRs), which might present new therapeutic targets to attenuate chronic pain. Dopamine rece...

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Detalles Bibliográficos
Autores principales: Dai, Wen-Ling, Bao, Yi-Ni, Fan, Ji-Fa, Ma, Bin, Li, Shan-Shan, Zhao, Wan-Li, Yu, Bo-Yang, Liu, Ji-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753228/
https://www.ncbi.nlm.nih.gov/pubmed/33364051
http://dx.doi.org/10.1016/j.jare.2020.08.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753228/
https://www.ncbi.nlm.nih.gov/pubmed/33364051
http://dx.doi.org/10.1016/j.jare.2020.08.005

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