LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases

BACKGROUND: Live kinase B1 (LKB1) is a tumor suppressor that is mutated in Peutz-Jeghers syndrome (PJS) and a variety of cancers. Lkb1 encodes serine-threonine kinase (STK) 11 that activates AMP-activated protein kinase (AMPK) and its 13 superfamily members, regulating multiple biological processes,...

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Detalles Bibliográficos
Autores principales: Zhang, Yanghe, Meng, Qingfei, Sun, Qianhui, Xu, Zhi-Xiang, Zhou, Honglan, Wang, Yishu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753952/
https://www.ncbi.nlm.nih.gov/pubmed/33278637
http://dx.doi.org/10.1016/j.molmet.2020.101131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753952/
https://www.ncbi.nlm.nih.gov/pubmed/33278637
http://dx.doi.org/10.1016/j.molmet.2020.101131

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