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LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases
BACKGROUND: Live kinase B1 (LKB1) is a tumor suppressor that is mutated in Peutz-Jeghers syndrome (PJS) and a variety of cancers. Lkb1 encodes serine-threonine kinase (STK) 11 that activates AMP-activated protein kinase (AMPK) and its 13 superfamily members, regulating multiple biological processes,...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753952/ https://www.ncbi.nlm.nih.gov/pubmed/33278637 http://dx.doi.org/10.1016/j.molmet.2020.101131 |