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Selection-driven tumor evolution with public goods leads to patterns of clonal expansion consistent with neutral growth

Cancers are the result of eco-evolutionary processes fueled by heritable phenotypic diversification and driven by environmentally dependent selection. Space represents a key growth-limiting ecological resource, the ability to explore this resource is likely under strong selection. Using agent-based...

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Detalles Bibliográficos
Autores principales: Edwards, Jack, Marusyk, Andriy, Basanta, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753957/
https://www.ncbi.nlm.nih.gov/pubmed/33364589
http://dx.doi.org/10.1016/j.isci.2020.101901