DEK‐targeting aptamer DTA‐64 attenuates bronchial EMT‐mediated airway remodelling by suppressing TGF‐β1/Smad, MAPK and PI3K signalling pathway in asthma

This study is to investigate the inhibitory effects and mechanisms of DEK‐targeting aptamer (DTA‐64) on epithelial mesenchymaltransition (EMT)‐mediated airway remodelling in mice and human bronchial epithelial cell line BEAS‐2B. In the ovalbumin (OVA)‐induced asthmatic mice, DTA‐64 significantly red...

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Detalles Bibliográficos
Autores principales: Song, Yilan, Wang, Zhiguang, Jiang, Jingzhi, Piao, Yihua, Li, Li, Xu, Chang, Piao, Hongmei, Li, Liangchang, Yan, Guanghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754001/
https://www.ncbi.nlm.nih.gov/pubmed/33124760
http://dx.doi.org/10.1111/jcmm.15942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754001/
https://www.ncbi.nlm.nih.gov/pubmed/33124760
http://dx.doi.org/10.1111/jcmm.15942

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