PDE1 or PDE5 inhibition augments NO‐dependent hypoxic constriction of porcine coronary artery via elevating inosine 3′,5′‐cyclic monophosphate level

Hypoxic coronary vasospasm may lead to myocardial ischaemia and cardiac dysfunction. Inosine 3′,5′‐cyclic monophosphate (cIMP) is a putative second messenger to mediate this pathological process. Nevertheless, it remains unclear as to whether levels of cIMP can be regulated in living tissue such as...

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Detalles Bibliográficos
Autores principales: Nan, Yan, Zeng, Xueqin, Jin, Zhiyi, Li, Na, Chen, Zhengju, Chen, Jiantong, Wang, Dezhong, Wang, Yang, Lin, Zhenlang, Ying, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754025/
https://www.ncbi.nlm.nih.gov/pubmed/33169529
http://dx.doi.org/10.1111/jcmm.16078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754025/
https://www.ncbi.nlm.nih.gov/pubmed/33169529
http://dx.doi.org/10.1111/jcmm.16078

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