Farnesoid X receptor activation induces antitumour activity in colorectal cancer by suppressing JAK2/STAT3 signalling via transactivation of SOCS3 gene

Farnesoid X receptor (FXR, encoded by NR1H4), a bile acid‐activated nuclear receptor, is widely implicated in human tumorigenesis. The FXR agonist obeticholic acid (OCA) has preliminarily displayed tumour suppressor potential. However, the anticancer effects of this agent on colorectal cancer (CRC)...

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Detalles Bibliográficos
Autores principales: Li, Shan, Xu, Zhengshui, Guo, Jing, Zheng, Jianbao, Sun, Xuejun, Yu, Junhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754034/
https://www.ncbi.nlm.nih.gov/pubmed/33164339
http://dx.doi.org/10.1111/jcmm.16083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754034/
https://www.ncbi.nlm.nih.gov/pubmed/33164339
http://dx.doi.org/10.1111/jcmm.16083

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