Towards Zwitterionic Oligonucleotides with Improved Properties: the NAA/LNA‐Gapmer Approach

Oligonucleotides (ON) are promising therapeutic candidates, for instance by blocking endogenous mRNA (antisense mechanism). However, ON usually require structural modifications of the native nucleic acid backbone to ensure satisfying pharmacokinetic properties. One such strategy to design novel anti...

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Detalles Bibliográficos
Autores principales: Wojtyniak, Melissa, Schmidtgall, Boris, Kirsch, Philine, Ducho, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754139/
https://www.ncbi.nlm.nih.gov/pubmed/32662164
http://dx.doi.org/10.1002/cbic.202000450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754139/
https://www.ncbi.nlm.nih.gov/pubmed/32662164
http://dx.doi.org/10.1002/cbic.202000450

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