Elevated In Vitro Kinase Activity in Peripheral Blood Mononuclear Cells of Leucine‐Rich Repeat Kinase 2 G2019S Carriers: A Novel Enzyme‐Linked Immunosorbent Assay–Based Method

BACKGROUND: Leucine‐rich repeat kinase 2 kinase inhibitors are being vigorously pursued as potential therapeutic options; however, there is a critical need for sensitive and quantitative assays of leucine‐rich repeat kinase 2 function and target engagement. OBJECTIVES: Our objective was to compare c...

Descripción completa

Detalles Bibliográficos
Autores principales: Melachroinou, Katerina, Kang, Min Suk, Liong, Christopher, Narayan, Sushma, Levers, Najah, Joshi, Neal, Kopil, Katie, Hutten, Samantha J., Baptista, Marco A.S., Padmanabhan, Shalini, Kang, Un Jung, Stefanis, Leonidas, Alcalay, Roy N., Rideout, Hardy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Regular Issue Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754308/
https://www.ncbi.nlm.nih.gov/pubmed/32652692
http://dx.doi.org/10.1002/mds.28175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754308/
https://www.ncbi.nlm.nih.gov/pubmed/32652692
http://dx.doi.org/10.1002/mds.28175

Ejemplares similares