An Adaptive Physiologically Based Pharmacokinetic–Driven Design to Investigate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics of Molibresib (GSK525762) in Healthy Female Volunteers

Molibresib (GSK525762), an orally bioavailable small molecule with 2 major equipotent active metabolites, is being developed for the treatment of cancers. Molibresib is a substrate of cytochrome P450 (CYP) 3A4 and P‐glycoprotein (P‐gp). To enable administering safe doses of molibresib to healthy vol...

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Detalles Bibliográficos
Autores principales: Riddell, Kylie, Patel, Aarti, Collins, Gary, Zhou, Yanyan, Schramek, Dan, Kremer, Brandon E., Ferron‐Brady, Geraldine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Women's Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754455/
https://www.ncbi.nlm.nih.gov/pubmed/32820548
http://dx.doi.org/10.1002/jcph.1711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754455/
https://www.ncbi.nlm.nih.gov/pubmed/32820548
http://dx.doi.org/10.1002/jcph.1711

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