Cargando…

Structure‐Based Design of Fluorogenic Substrates Selective for Human Proteasome Subunits

Proteasomes are established therapeutic targets for hematological cancers and promising targets for autoimmune diseases. In the past, we have designed and synthesized mechanism‐based proteasome inhibitors that are selective for the individual catalytic activities of human constitutive proteasomes an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maurits, Elmer, Degeling, Christian G., Kisselev, Alexei F., Florea, Bogdan I., Overkleeft, Herman S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754458/ https://www.ncbi.nlm.nih.gov/pubmed/32598532 http://dx.doi.org/10.1002/cbic.202000375

Ejemplares similares

Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits
por: Xin, Bo-Tao, et al.
Publicado: (2019)

The ATP/Mg(2+) Balance Affects the Degradation of Short Fluorogenic Substrates by the 20S Proteasome
por: Morozov, Alexey, et al.
Publicado: (2022)

Assessing Subunit Dependency of the Plasmodium Proteasome Using Small Molecule Inhibitors and Active Site Probes
por: Li, Hao, et al.
Publicado: (2014)

Development of a DUB-selective fluorogenic substrate
por: Gjonaj, Lorina, et al.
Publicado: (2019)

Evaluation of Immunoproteasome-Specific Proteolytic Activity Using Fluorogenic Peptide Substrates
por: Kim, Sumin, et al.
Publicado: (2022)

Site-Specific Proteasome Inhibitors
por: Kisselev, Alexei F.
Publicado: (2021)

Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates
por: Sandu, Cristinel, et al.
Publicado: (2015)

Fluorogenic Bifunctional trans‐Cyclooctenes as Efficient Tools for Investigating Click‐to‐Release Kinetics
por: de Geus, Mark A. R., et al.
Publicado: (2020)

High Immunoproteasome Activity and sXBP1 in Pediatric Precursor B-ALL Predicts Sensitivity towards Proteasome Inhibitors
por: Besse, Lenka, et al.
Publicado: (2021)

Recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2
por: Ibtisam, Ibtisam, et al.
Publicado: (2023)

The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells
por: Kraus, Johannes, et al.
Publicado: (2015)

Structure-based rational design of an enhanced fluorogen-activating protein for fluorogens based on GFP chromophore
por: Goncharuk, Marina V., et al.
Publicado: (2022)

High-dose carfilzomib achieves superior anti-tumor activity over low-dose and recaptures response in relapsed/refractory multiple myeloma resistant to low-dose carfilzomib by co-inhibiting the β2 and β1 subunits of the proteasome complex
por: Zhou, Xiang, et al.
Publicado: (2023)

Development of a fluorogenic ADAMTS-7 substrate
por: Santamaria, Salvatore, et al.
Publicado: (2021)

Fluorogenic Peptide Substrate for Quantification of Bacterial Enzyme Activities
por: Al-Abdullah, Ismail H., et al.
Publicado: (2017)

Fluorogenic Substrates for Visualizing Acidic Organelle Enzyme Activities
por: Harlan, Fiona Karen, et al.
Publicado: (2016)

Immunoproteasome Activity in Chronic Lymphocytic Leukemia as a Target of the Immunoproteasome-Selective Inhibitors
por: Besse, Andrej, et al.
Publicado: (2022)

Proteasome Activity Profiling Uncovers Alteration of Catalytic β2 and β5 Subunits of the Stress-Induced Proteasome during Salinity Stress in Tomato Roots
por: Kovács, Judit, et al.
Publicado: (2017)

Mechanism‐Based Fluorogenic trans‐Cyclooctene–Tetrazine Cycloaddition
por: Vázquez, Arcadio, et al.
Publicado: (2016)

Fluorogenic and Bioorthogonal Modification of RNA Using Photoclick Chemistry
por: Krell, Katja, et al.
Publicado: (2020)

Supramolecular Fluorescence Resonance Energy Transfer in Nucleobase‐Modified Fluorogenic RNA Aptamers
por: Steinmetzger, Christian, et al.
Publicado: (2020)

Development of a fluorogenic small substrate for dipeptidyl peptidase-4
por: Ogawa, Futa, et al.
Publicado: (2017)

A Role for the Proteasome Alpha2 Subunit N-Tail in Substrate Processing
por: Sahu, Indrajit, et al.
Publicado: (2023)

Non‐lethal proteasome inhibition activates pro‐tumorigenic pathways in multiple myeloma cells
por: Skorda, Aikaterini, et al.
Publicado: (2019)

A Facile Fluorometric Assay of Orotate Phosphoribosyltransferase Activity Using a Selective Fluorogenic Reaction for Orotic Acid
por: Shibata, Takayuki, et al.
Publicado: (2023)

An Extended Approach for the Development of Fluorogenic trans‐Cyclooctene–Tetrazine Cycloadditions
por: Siegl, Sebastian J., et al.
Publicado: (2019)

Fluorogenic Substrates for In Situ Monitoring of Caspase-3 Activity in Live Cells
por: Pérez-López, Ana M., et al.
Publicado: (2016)

Substrate selection by the proteasome during degradation of protein complexes
por: Prakash, Sumit, et al.
Publicado: (2008)

A BODIPY-Based Fluorogenic Probe for Specific Imaging of Lipid Droplets
por: Li, Guanglei, et al.
Publicado: (2020)

HaloTag Engineering for Enhanced Fluorogenicity and Kinetics with a Styrylpyridium Dye
por: Miró‐Vinyals, Carla, et al.
Publicado: (2021)

Bortezomib Amplifies Effect on Intracellular Proteasomes by Changing Proteasome Structure()
por: Pitcher, David S., et al.
Publicado: (2015)

Proteasome in action: substrate degradation by the 26S proteasome
por: Sahu, Indrajit, et al.
Publicado: (2021)

Synthesis and Evaluation of a Selective Fluorogenic Pup Derived Assay Reagent for Dop, a Potential Drug Target in Mycobacterium tuberculosis
por: Merkx, Remco, et al.
Publicado: (2012)

N-Terminal Coiled-Coil Structure of ATPase Subunits of 26S Proteasome Is Crucial for Proteasome Function
por: Inobe, Tomonao, et al.
Publicado: (2015)

Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate()
por: Kuo, Chih-Jung, et al.
Publicado: (2004)

Development of fluorogenic substrates for colorectal tumor-related neuropeptidases for activity-based diagnosis
por: Nagano, Norimichi, et al.
Publicado: (2023)

Fluorescent Rhodamines and Fluorogenic Carbopyronines for Super‐Resolution STED Microscopy in Living Cells
por: Butkevich, Alexey N., et al.
Publicado: (2016)

Fluorogenic Ag(+)–Tetrazolate Aggregation Enables Efficient Fluorescent Biological Silver Staining
por: Xie, Sheng, et al.
Publicado: (2018)

Oligonucleotide Labelling Using a Fluorogenic “Click” Reaction with a Hemicarboxonium Salt
por: Maether, Marie-Pierre, et al.
Publicado: (2013)

Structure and function based design of Plasmodium-selective proteasome inhibitors
por: Li, Hao, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_gsmhvcbn4djne59m7hk1v0uu82