Structure‐Based Design of Fluorogenic Substrates Selective for Human Proteasome Subunits

Proteasomes are established therapeutic targets for hematological cancers and promising targets for autoimmune diseases. In the past, we have designed and synthesized mechanism‐based proteasome inhibitors that are selective for the individual catalytic activities of human constitutive proteasomes an...

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Detalles Bibliográficos
Autores principales: Maurits, Elmer, Degeling, Christian G., Kisselev, Alexei F., Florea, Bogdan I., Overkleeft, Herman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754458/
https://www.ncbi.nlm.nih.gov/pubmed/32598532
http://dx.doi.org/10.1002/cbic.202000375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754458/
https://www.ncbi.nlm.nih.gov/pubmed/32598532
http://dx.doi.org/10.1002/cbic.202000375

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