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Combining PARP Inhibition with Platinum, Ruthenium or Gold Complexes for Cancer Therapy

Platinum drugs are heavily used first‐line chemotherapeutic agents for many solid tumours and have stimulated substantial interest in the biological activity of DNA‐binding metal complexes. These complexes generate DNA lesions which trigger the activation of DNA damage response (DDR) pathways that a...

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Detalles Bibliográficos
Autores principales: Yusoh, Nur Aininie, Ahmad, Haslina, Gill, Martin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754470/
https://www.ncbi.nlm.nih.gov/pubmed/32812709
http://dx.doi.org/10.1002/cmdc.202000391