Pharmacokinetics and Pharmacodynamics of Subcutaneous Sarilumab and Intravenous Tocilizumab Following Single‐Dose Administration in Patients With Active Rheumatoid Arthritis on Stable Methotrexate

We assessed pharmacokinetics (PK), pharmacodynamics (PD), and PK/PD relationships of interleukin‐6 (IL‐6), soluble IL‐6 receptor, and C‐reactive protein (CRP) in serum, and absolute neutrophil count (ANC) in blood following single doses of subcutaneous sarilumab versus intravenous tocilizumab (NCT02...

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Detalles Bibliográficos
Autores principales: Paccaly, Anne J., Kovalenko, Pavel, Parrino, Janie, Boyapati, Anita, Xu, Christine, van Hoogstraten, Hubert, Ishii, Tomonori, Davis, John D., DiCioccio, A. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Pharmacokinetics/Pharmacodynamics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754484/
https://www.ncbi.nlm.nih.gov/pubmed/32726514
http://dx.doi.org/10.1002/jcph.1703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754484/
https://www.ncbi.nlm.nih.gov/pubmed/32726514
http://dx.doi.org/10.1002/jcph.1703

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