Mitochondrial defects in the respiratory complex I contribute to impaired translational initiation via ROS and energy homeostasis in SMA motor neurons

Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by loss of lower motor neurons, which leads to proximal muscle weakness and atrophy. SMA is caused by reduced survival motor neuron (SMN) protein levels due to biallelic deletions or mutations in the SMN1 gene. When SMN levels fa...

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Detalles Bibliográficos
Autores principales: Thelen, Maximilian Paul, Wirth, Brunhilde, Kye, Min Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754598/
https://www.ncbi.nlm.nih.gov/pubmed/33353564
http://dx.doi.org/10.1186/s40478-020-01101-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754598/
https://www.ncbi.nlm.nih.gov/pubmed/33353564
http://dx.doi.org/10.1186/s40478-020-01101-6

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