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Design of novel granulopoietic proteins by topological rescaffolding

Computational protein design is rapidly becoming more powerful, and improving the accuracy of computational methods would greatly streamline protein engineering by eliminating the need for empirical optimization in the laboratory. In this work, we set out to design novel granulopoietic agents using...

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Detalles Bibliográficos
Autores principales: Hernandez Alvarez, Birte, Skokowa, Julia, Coles, Murray, Mir, Perihan, Nasri, Masoud, Maksymenko, Kateryna, Weidmann, Laura, Rogers, Katherine W., Welte, Karl, Lupas, Andrei N., Müller, Patrick, ElGamacy, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755208/
https://www.ncbi.nlm.nih.gov/pubmed/33351791
http://dx.doi.org/10.1371/journal.pbio.3000919