Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome

Pyrrole–imidazole (Py–Im) polyamides are synthetic molecules that can be rationally designed to target specific DNA sequences to both disrupt and recruit transcriptional machinery. While in vitro binding has been extensively studied, in vivo effects are often difficult to predict using current model...

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Detalles Bibliográficos
Autores principales: Finn, Paul B., Bhimsaria, Devesh, Ali, Asfa, Eguchi, Asuka, Ansari, Aseem Z., Dervan, Peter B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755219/
https://www.ncbi.nlm.nih.gov/pubmed/33351840
http://dx.doi.org/10.1371/journal.pone.0243905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755219/
https://www.ncbi.nlm.nih.gov/pubmed/33351840
http://dx.doi.org/10.1371/journal.pone.0243905

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