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Efficient weighted univariate clustering maps outstanding dysregulated genomic zones in human cancers

MOTIVATION: Chromosomal patterning of gene expression in cancer can arise from aneuploidy, genome disorganization or abnormal DNA methylation. To map such patterns, we introduce a weighted univariate clustering algorithm to guarantee linear runtime, optimality and reproducibility. RESULTS: We presen...

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Detalles Bibliográficos
Autores principales: Song, Mingzhou, Zhong, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755420/
https://www.ncbi.nlm.nih.gov/pubmed/32619008
http://dx.doi.org/10.1093/bioinformatics/btaa613