Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops

Antibodies are critical components of adaptive immunity, binding with high affinity to pathogenic epitopes. Antibodies undergo rigorous selection to achieve this high affinity, yet some maintain an additional basal level of low affinity, broad reactivity to diverse epitopes, a phenomenon termed ‘pol...

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Detalles Bibliográficos
Autores principales: Boughter, Christopher T, Borowska, Marta T, Guthmiller, Jenna J, Bendelac, Albert, Wilson, Patrick C, Roux, Benoit, Adams, Erin J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755423/
https://www.ncbi.nlm.nih.gov/pubmed/33169668
http://dx.doi.org/10.7554/eLife.61393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755423/
https://www.ncbi.nlm.nih.gov/pubmed/33169668
http://dx.doi.org/10.7554/eLife.61393

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