The first intracellular loop is essential for the catalytic cycle of the human ABCG2 multidrug resistance transporter

The human multidrug transporter ABCG2 is required for physiological detoxification and mediates anticancer drug resistance. Here, we identify pivotal residues in the first intracellular loop (ICL1), constituting an intrinsic part of the transmission interface. The architecture includes a triple heli...

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Detalles Bibliográficos
Autores principales: Khunweeraphong, Narakorn, Kuchler, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756363/
https://www.ncbi.nlm.nih.gov/pubmed/33169382
http://dx.doi.org/10.1002/1873-3468.13994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756363/
https://www.ncbi.nlm.nih.gov/pubmed/33169382
http://dx.doi.org/10.1002/1873-3468.13994

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