Genomics‐Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism

A gene cluster encoding a cryptic trans‐acyl transferase polyketide synthase (PKS) was identified in the genomes of Burkholderia gladioli BCC0238 and BCC1622, both isolated from the lungs of cystic fibrosis patients. Bioinfomatics analyses indicated the PKS assembles a novel member of the glutarimid...

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Detalles Bibliográficos
Autores principales: Nakou, Ioanna T., Jenner, Matthew, Dashti, Yousef, Romero‐Canelón, Isolda, Masschelein, Joleen, Mahenthiralingam, Eshwar, Challis, Gregory L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756379/
https://www.ncbi.nlm.nih.gov/pubmed/32918852
http://dx.doi.org/10.1002/anie.202009007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756379/
https://www.ncbi.nlm.nih.gov/pubmed/32918852
http://dx.doi.org/10.1002/anie.202009007

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