Syntheses of Thailandepsin B Pseudo‐Natural Products: Access to New Highly Potent HDAC Inhibitors via Late‐Stage Modification

New Thailandepsin B pseudo‐natural products have been prepared. Our synthetic strategy offers the possibility to introduce varying warheads via late stage modification. Additionally, it gives access to the asymmetric branched allylic ester moiety of the natural product in a highly diastereoselective...

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Detalles Bibliográficos
Autores principales: Brosowsky, Jana, Lutterbeck, Monika, Liebich, Amelie, Keller, Manfred, Herp, Daniel, Vogelmann, Anja, Jung, Manfred, Breit, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756392/
https://www.ncbi.nlm.nih.gov/pubmed/32725698
http://dx.doi.org/10.1002/chem.202002449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756392/
https://www.ncbi.nlm.nih.gov/pubmed/32725698
http://dx.doi.org/10.1002/chem.202002449

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