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Quadruplex–Duplex Junction: A High‐Affinity Binding Site for Indoloquinoline Ligands

A parallel quadruplex derived from the Myc promoter sequence was extended by a stem‐loop duplex at either its 5′‐ or 3′‐terminus to mimic a quadruplex–duplex (Q–D) junction as a potential genomic target. High‐resolution structures of the hybrids demonstrate continuous stacking of the duplex on the q...

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Detalles Bibliográficos
Autores principales: Vianney, Yoanes Maria, Preckwinkel, Pit, Mohr, Swantje, Weisz, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756412/
https://www.ncbi.nlm.nih.gov/pubmed/32975874
http://dx.doi.org/10.1002/chem.202003540