Insect‐Associated Bacteria Assemble the Antifungal Butenolide Gladiofungin by Non‐Canonical Polyketide Chain Termination

Genome mining of one of the protective symbionts (Burkholderia gladioli) of the invasive beetle Lagria villosa revealed a cryptic gene cluster that codes for the biosynthesis of a novel antifungal polyketide with a glutarimide pharmacophore. Targeted gene inactivation, metabolic profiling, and bioas...

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Detalles Bibliográficos
Autores principales: Niehs, Sarah P., Kumpfmüller, Jana, Dose, Benjamin, Little, Rory F., Ishida, Keishi, Flórez, Laura V., Kaltenpoth, Martin, Hertweck, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756420/
https://www.ncbi.nlm.nih.gov/pubmed/32588959
http://dx.doi.org/10.1002/anie.202005711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756420/
https://www.ncbi.nlm.nih.gov/pubmed/32588959
http://dx.doi.org/10.1002/anie.202005711

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