Protein‐Templated Hit Identification through an Ugi Four‐Component Reaction

Kinetic target‐guided synthesis represents an efficient hit‐identification strategy, in which the protein assembles its own inhibitors from a pool of complementary building blocks via an irreversible reaction. Herein, we pioneered an in situ Ugi reaction for the identification of novel inhibitors of...

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Detalles Bibliográficos
Autores principales: Mancini, Federica, Unver, M. Yagiz, Elgaher, Walid A. M., Jumde, Varsha R., Alhayek, Alaa, Lukat, Peer, Herrmann, Jennifer, Witte, Martin D., Köck, Matthias, Blankenfeldt, Wulf, Müller, Rolf, Hirsch, Anna K. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756422/
https://www.ncbi.nlm.nih.gov/pubmed/32428268
http://dx.doi.org/10.1002/chem.202002250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756422/
https://www.ncbi.nlm.nih.gov/pubmed/32428268
http://dx.doi.org/10.1002/chem.202002250

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