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Bifunctional Reagents for Formylglycine Conjugation: Pitfalls and Breakthroughs
Formylglycine‐generating enzymes specifically oxidize cysteine within the consensus sequence CxPxR to C(α)‐formylglycine (FGly). This noncanonical electrophilic amino acid can subsequently be addressed selectively by bioorthogonal hydrazino‐iso‐Pictet‐Spengler (HIPS) or Knoevenagel ligation to attac...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756428/ https://www.ncbi.nlm.nih.gov/pubmed/32767537 http://dx.doi.org/10.1002/cbic.202000416 |